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An Enantioselective Synthesis of ( S )-(+)-3-Aminomethyl-5-methylhexanoic Acid via Asymmetric Hydrogenation

โœ Scribed by Burk, Mark J.; de Koning, Pieter D.; Grote, Todd M.; Hoekstra, Marvin S.; Hoge, Garrett; Jennings, Rex A.; Kissel, William S.; Le, Tung V.; Lennon, Ian C.; Mulhern, Thomas A.; Ramsden, James A.; Wade, Robert A.


Book ID
117990739
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
69 KB
Volume
68
Category
Article
ISSN
0022-3263

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โœ Estelle Coulon; Maria Cristina Caรฑo de Andrade; Virginie Ratovelomanana-Vidal; J ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 207 KB

An efficient synthesis of the natural occuring amino acid (2S.3R)-3-hydroxylysine is reported. The five step sequence features a highly enantioselective dynamic kinetic resolution of racemic o~acetamido [J-keto phtidimidohexanoate using ruthenium(ll) catalyzed hydrogenation reaction.