✦ LIBER ✦

An enantioselective synthesis of a key intermediate to thienamycin by chemicoenzymatic approach

✍ Scribed by Harumi Kaga; Susumu Kobayashi; Masaji Ohno

Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 320 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/0040-4039(88)85334-6

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

A stereoselective route to the key inter

A stereoselective route to the key intermediate of 1β-methylcarbapenems by chemicoenzymatic approach

✍ Harumi Kaga; Susumu Kobayashi; Masaji Ohno 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 270 KB

A general approach to trans-carbapenem a

A general approach to trans-carbapenem antibiotics. Enantioselective synthesis of key intermediates for (+)-PS-5, (+)-PS-6, and (+)-thienamycin

✍ Kazuo Okano; Toshio Izawa; Masaji Ohno 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 239 KB

An enantioselective approach to carbapen

An enantioselective approach to carbapenem antibiotics: formal synthesis of (+)-thienamycin

✍ David J. Hart; Deok-Chan Ha 📂 Article 📅 1985 🏛 Elsevier Science 🌐 French ⚖ 219 KB

An enantioselective synthesis of intermediates in syntheses of thienamycin (15) and epithienamycin-C (16) is described. Several years ago we reported that N-trimethylsilyl imines react with ester enolates to afford l-unsubstituted-B-lactams. 1 We also showed that ethyl B-hydroxybutyrate would serve

An enantioselective synthesis of the A-r

An enantioselective synthesis of the A-ring synthon for vitamin D3 metabolites by chemicoenzymatic approach

✍ Susumu Kobayashi; Jun Shibata; Mitsuyuki Shimada; Masaji Ohno 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 258 KB

An efficient enantioselective synthesis

An efficient enantioselective synthesis of the carbapenam-2-one system. An approach to (+)-thienamycin and related carbapenems

✍ A.I. Meyers; Thomas J. Sowin; Stefan Scholz; Yasutsugu Ueda 📂 Article 📅 1987 🏛 Elsevier Science 🌐 French ⚖ 215 KB

Cycloaddition of the enantiomeric 4-acetoxy-2-azetidinone (5) with the 2-siloxy-1,3butadiene (8) gives the carbacephem 9 which is cleaved via ozone and cyclized to the carbapenem system (+)-13 in 30% overall yield. The extensive activity directed toward the carbapenem systems (1, 2) due to their hig

Enantioselective route to a key intermed

Enantioselective route to a key intermediate in the total synthesis of forskolin

✍ E.J. Corey; Paul Da Silva Jardine; Tetsuya Mohri 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 217 KB

An enantioselective route for the total synthesis of forskolin, a potent activator of adenylate cyclase, has been developed which is based on reduction of dienone 3 to the (S)-alcohol4 and conversion in two steps to tricyclic lactone 9, obtained in optically pure form simply by recrystallization. A