An Enantioselective Route to α-Methyl Carboxylic Acids via Metal and Enzyme Catalysis
✍ Scribed by Norinder, Jakob; Bogár, Krisztián; Kanupp, Lisa; Bäckvall, Jan-E.
- Book ID
- 126980902
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 89 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
## Abstract α‐Methyllysine and 2‐amino‐2‐methylundecanoic acid, two α,α‐disubstituted unnatural glycines, were synthesized using highly diastereoselective allylation or propargylation of chiral (1__S__,2__R__,4__R__)‐10‐dicyclohexylsulfamoylisobornyl 2‐cyanopropanoate as the key step to introduce t
Radical addition to a glyoxylic oxime ether was accomplished under mild conditions using an alkyl radical generated from a free carboxylic acid via photochemical decarboxylation. The photoreaction provided an efficient route to a-substituted a-aminoesters from carboxylic acids and oxime ether.