Addition of alkyl radicals, generated from carboxylic acids via photochemical decarboxylation, to glyoxylic oxime ether: a mild and efficient route to α-substituted α-aminoesters

✍ Scribed by Yasuharu Yoshimi; Kosuke Kobayashi; Hayato Kamakura; Keisuke Nishikawa; Yoshiki Haga; Kousuke Maeda; Toshio Morita; Tatsuya Itou; Yutaka Okada; Minoru Hatanaka

• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 505 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.02.112

✦ Synopsis

Radical addition to a glyoxylic oxime ether was accomplished under mild conditions using an alkyl radical generated from a free carboxylic acid via photochemical decarboxylation. The photoreaction provided an efficient route to a-substituted a-aminoesters from carboxylic acids and oxime ether.