An Emerging Model for BAP1’s Role in Regulating Cell Cycle Progression
✍ Scribed by Ziad M. Eletr; Keith D. Wilkinson
- Book ID
- 107567825
- Publisher
- Springer-Verlag
- Year
- 2011
- Tongue
- English
- Weight
- 291 KB
- Volume
- 60
- Category
- Article
- ISSN
- 1085-9195
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Androgen‐ablation is a most commonly prescribed treatment for metastatic prostate cancer but it is not curative. Development of new strategies for treatment of prostate cancer is limited partly by a lack of full understanding of the mechanism by which androgen regulates prostate cancer
The mechanism of the G0/G1 arrest and inhibition of proliferation by quinidine, a potassium channel blocker, was investigated in a tissue culture cell line, MCF-7, derived from a human breast carcinoma. The earliest measurable effect of quinidine on the cell cycle was a decrease in the fraction of c