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An electron microscopic and biochemical study of the effects of glucagon on glycogen autophagy in the liver and heart of newborn rats

✍ Scribed by D.J. Kondomerkos; S.A. Kalamidas; O.B. Kotoulas

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
460 KB
Volume
63
Category
Article
ISSN
1059-910X

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✦ Synopsis

Abstract

The effects of glucagon on the ultrastructural appearance and acid glucosidase activities in the liver and heart of newborn rats were studied. Liver or heart glycogen‐hydrolyzing activity of acid glucosidase increased 3 hours after birth and gradually decreased from 3 to 9 hours. Maltose‐hydrolyzing activity of acid glucosidase also rose 3 hours after birth, maintained a plateau between 3 and 6 hours, and fell at 9 hours. The administration of glucagon increased autophagic activity in the hepatocytes at the age of 6 hours. Glycogen inside the autophagic vacuoles was decreased, apparently due to the increased glycogen degradation. Glycogen‐hydrolyzing activity was elevated in both the liver and the heart. Maltose‐hydrolyzing activity was elevated in the liver, but not in the heart. The results of this study suggest that the glycogen‐hydrolyzing and maltose‐hydrolyzing activities of acid glucosidase are due to different enzymes. Glucagon's effect on the glycogen‐hydrolyzing acid glucosidase activity and autophagosomal morphology is similar in both the liver and the heart. Microsc. Res. Tech. 63:87–93, 2004. © 2004 Wiley‐Liss, Inc.

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