An Efficient Synthesis of [(Tosylamino)alkyl]naphthalenols by Nucleophilic Addition of Naphthalen-2-ol with N-Tosyl Imines Using Boron Trifluoride Etherate as Catalyst

✍ Scribed by Biswanath Das; Cheruku Ravindra Reddy; Chava Sindhu; Duddukuri Nandan Kumar; Martha Krishnaiah

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: German
• Weight: 124 KB
• Volume: 94
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.201000224

✦ Synopsis

Tosylamino)alkyl]naphthalenols have efficiently been synthesized by nucleophilic addition of naphthalen-2-ol with N-tosyl imines (derived from both aromatic and aliphatic aldehydes) in the presence of BF 3 • OEt 2 as a catalyst at room temperature. The products are formed within 5 -9 h in high yields (72 -91%).