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An Efficient Synthesis of Racemic 4-Hydroxy-2-oxo-1-pyrrolidineacetamide (Oxiracetam) Using Tetramic-Acid Intermediates

✍ Scribed by David D. P. Laffan; Markus Bänziger; Lauren Duc; Andrew R. Evans; John F. McGarrity; Thomas Meul


Publisher
John Wiley and Sons
Year
1992
Tongue
German
Weight
570 KB
Volume
75
Category
Article
ISSN
0018-019X

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✍ Glen W. Spears; Kiyoshi Tsuji; Takashi Tojo; Hiroaki Nishimura; Takashi Ogino 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 68 KB

## Abstract The novel title compounds have been prepared in high yield by an optimized amide coupling followed by a Dieckmann cyclization. Additionally, this new route is amenable to preparative scale synthesis.