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An Efficient Synthesis of Novel Heterocycle-Fused Derivatives of 1-Oxo-1,2,3,4-tetrahydropyrazine Using Ugi Condensation.

✍ Scribed by Alexey P. Ilyn; Julia A. Kuzovkova; Victor V. Potapov; Alexandre M. Shkirando; Denis I. Kovrigin; Sergey E. Tkachenko; Alexandre V. Ivachtchenko

Publisher: John Wiley and Sons
Year: 2005
Weight: 23 KB
Volume: 36
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200520158

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## Abstract The novel title compounds have been prepared in high yield by an optimized amide coupling followed by a Dieckmann cyclization. Additionally, this new route is amenable to preparative scale synthesis.