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An efficient synthesis of R3Si(CH2)n-substituted acetylacetone derivatives

✍ Scribed by Urbaniak, Wlodzimierz ;Schubert, Ulrich

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
328 KB
Volume
1991
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

An efficient synthesis of R~3~Si(CH~2~)~3~CH[C(O)Me]~2~ 3 [R = Me, ORβ€²] is described. The reaction of R~3~Si(CH~2~)~3~Cl 2 with the sodium of potassium salt of acetylacetonate (1) and 0.8–2 equivalents of NaI of KI in DMF, DMSO or NMP as a solvent gives the C‐ and O‐alkylation products R~3~Si(CH~2~)~3~CH[C(O)Me]~2~ 3 and R~3~Si(CH~2~)~3~OC(Me)ο£ΎCHο£ΏC(O)Me 4 in a 3:1 ratio and a 60–70% total yield. For R~3~SiCH~2~CH[C(O)Me]~2~ selectivity and yields are lower.

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