An efficient synthesis of (±)-pinidine
✍ Scribed by Simeon Arseniyadis; Jacques Sartoretti
- Book ID
- 104222313
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 250 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The title alkaloid, (+)-1, was prepared in three steps from methyl acetoacetate and the chiral I~-amino cation synthon (-)-3.
Review: [2a]. A remarkable example is the employment of a chiral2-cyano-6-oxazolopiperidine as a pivotal intermediate for the synthesis of various piperidine alkaloids [2b].
A highly stcrcosclcctivc synthesis of (-)-bulgccininc (1) vita the pyrrolido[l~s]oxazolidin-3-one system (2) has been achieved by starting with the asymmetric epoxidation of the twin ally1 alcohol system (6). The transformation of note includes the palladium-catalyzed N-tn cyclixation leading exclus