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An efficient synthesis of (-)-bulgecinine

✍ Scribed by Yoshiro Hirai; Takashi Terada; Yoshiko Amemiya; Takefumi Momose

Book ID
104214781
Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
154 KB
Volume
33
Category
Article
ISSN
0040-4039

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✦ Synopsis

A highly stcrcosclcctivc synthesis of (-)-bulgccininc (1) vita the pyrrolido[l~s]oxazolidin-3-one system (2) has been achieved by starting with the asymmetric epoxidation of the twin ally1 alcohol system (6). The transformation of note includes the palladium-catalyzed N-tn cyclixation leading exclusively to a rruns-2.5disubstittltai pyn0Mine.

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