An efficient synthesis of (+)-oxybiotin from d-arabinose
✍ Scribed by Velimir Popsavin; Goran Benedeković; Mirjana Popsavin
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 116 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The efficient synthesis of sugar-derived triazoles via a one-pot substitution-cyclization-oxidation procedure is presented. Starting from D-arabinose and L-fucose, triazole structures as potential enzyme inhibitors were obtained in six to eight steps.
5-Thio-L-fucopyranose tetraacetate was synthesized in 11 steps from 5-O-trityl-D-arabinofuranose or D-arabinose diethyl dithioacetal by one-carbon elongation at C-5. Highly diastereoselective addition of MeLi in ether to a 1,2-O-isopropylidene-[J-D-arabino-pentodialdo-l,4-furanose derivative was ach
Polyoxamic acid , 2-amino-2-deoxy-L-xylonic acid, is synthetized by thiophenoxide opening of a five-carbon chiral hydroxylated aziridine easily derived from L-arabinose. The formation of the carboxy group resulted lrom a Pummerer reaction. Polyoxins belong to a group of antifungal antibiotics produc