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An efficient synthesis of ortho-N-Boc-arylmethyl ketone derivatives

✍ Scribed by Pierre-Emmanuel Broutin; Peter Hilty; Andrew W Thomas

Book ID: 104254201
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 131 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01597-1

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✦ Synopsis

A new and efficient method for the preparation of ortho-N-Boc-arylmethyl ketone derivatives is reported. The reaction involves the intermediacy of a 4-methylene-3,1-benzoaxin-2-one moiety which smoothly converts to the target compounds under acidic conditions. The ortho-N-Boc-arylmethyl ketone derivatives can be formed in a one-pot reaction or alternatively the 4-methylene-3,1-benzoaxin-2-ones can be isolated and subsequently transformed into the desired products.

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