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An efficient synthesis of N-Boc-(2S,3S)-3-hydroxy-2-phenyl piperidine and N-Boc-safingol

✍ Scribed by Rao, Maddimsetti Venkateswara; Reddy, Kotha kapu Sridhar; Rao, Batchu Venkateswara


Book ID
120011831
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
215 KB
Volume
53
Category
Article
ISSN
0040-4039

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A versatile and efficient synthesis of (
✍ A Shashidhar Kumar; B Haritha; B Venkateswara Rao πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 81 KB

A versatile and efficient method for the preparation of (2S)-2-(hydroxymethyl)-N-Boc-2,3-dihydro-4-pyridone from L-(-)-phenylalanine 2 utilising the aromatic system as a masked b-keto aldehyde was developed. The key step in the sequence is an intramolecular cyclisation of 6 to give 2,3-dihydropyridi