A versatile and efficient synthesis of (2S)-2-(hydroxymethyl)-N-Boc-2,3-dihydro-4-pyridone

✍ Scribed by A Shashidhar Kumar; B Haritha; B Venkateswara Rao

• Book ID: 104253633
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 81 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)00888-8

✦ Synopsis

A versatile and efficient method for the preparation of (2S)-2-(hydroxymethyl)-N-Boc-2,3-dihydro-4-pyridone from L-(-)-phenylalanine 2 utilising the aromatic system as a masked b-keto aldehyde was developed. The key step in the sequence is an intramolecular cyclisation of 6 to give 2,3-dihydropyridin-4-ones.