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An Efficient Synthesis of Nilotinib (AMN107)

✍ Scribed by Wei-Sheng Huang; William C. Shakespeare


Publisher
John Wiley and Sons
Year
2007
Weight
12 KB
Volume
38
Category
Article
ISSN
0931-7597

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## Abstract Blastmycinone, a degradation product of the antibiotic antimycin A, was synthesized with a TiCl~4~‐mediated asymmetric aldolization as the key step. Some unexpected yet interesting chemistry was also observed.