An efficient synthesis of new thiazolopyrimidinones under microwave irradiation

✍ Scribed by Serge Djekou; Armand Gellis; Patrice Vanelle; Hussein El-Kashef

• Book ID: 102346807
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2006
• Tongue: English
• Weight: 282 KB
• Volume: 43
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570430513

✦ Synopsis

7-Chloromethyl-6-nitro-5H-thiazolo[3,2-a]pyrimidin-5-one (2) is obtained by cyclocondensation of 2aminothiazole with ethyl 4-chloroacetoacetate. This product was shown to react with various nitronate or malonate anions under microwave irradiation to give potentially bioactive 6-nitro-5H-thiazolo[3,2-a]pyrimidin-5-ones. Extension to other anions centered on S atom allows for the generalization this synthetic procedure.