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An Efficient Synthesis of N -Methyl Amino Acids by Way of Intermediate 5-Oxazolidinones

✍ Scribed by Aurelio, Luigi; Box, John S.; Brownlee, Robert T. C.; Hughes, Andrew B.; Sleebs, Marianne M.


Book ID
121486832
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
308 KB
Volume
68
Category
Article
ISSN
0022-3263

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N-(Ξ±-Stannylalkyl) oxazolidinones can be obtained as a mixture of diastereomers in three steps from aldehydes with yields dependent on the R group of R-CHO. They can be transformed by a tin-lithium exchange to N-(Ξ±-lithioalkyl)oxazolidinones which equilibrate rapidly to one diastereomer. These comp