An efficient synthesis of indeno[1,2-b]pyridine and benzo[h]quinoline derivatives under solvent-free conditions

✍ Scribed by Liangce Rong; Hongxia Han; Hong Jiang; Shujiang Tu

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2009
• Tongue: English
• Weight: 108 KB
• Volume: 46
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.112

✦ Synopsis

Abstract

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An efficient and convenient multicomponent reaction for the preparation of 4‐aryl‐2‐oxo‐2,5‐dihydro‐1__H__‐indeno[1,2‐b]pyridine‐3‐carbonitrile and 4‐aryl‐2‐oxo‐1,2,5,6‐tetrahydrobenzo[h]quinoline‐3‐carbonitrile derivatives by the 2,3‐dihydroinden‐1‐one or 3,4‐dihydronaphthalen‐1(2__H__)‐one, aromatic aldehydes, and malononitrile in the presence of sodium hydroxide under solvent‐free condition is reported. The short reaction time coupled with the simplicity of the reaction procedure makes this method one of the most efficient methods for the synthesis of these classes of compounds. J. Heterocyclic Chem., 46, 465 (2009).