An Efficient Synthesis of Heterocyclic Analogs of 1-Arylnaphthalene Lignans
β Scribed by Kuroda, Tooru; Takahashi, Masami; Ogiku, Tsuyoshi; Ohmizu, Hiroshi; Nishitani, Takashi; Kondo, Kazuhiko; Iwasaki, Tameo
- Book ID
- 120468385
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 644 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
We established a convergent synthesis of S-8921 (1), a unique hypocholesterolemic lignan analog, in 9 steps, including concise preparations of phthalide 7 and acylpropenoate 10, and their regio-and stereocontrolled tandem anionic reactions leading to precursor 11 as a key step.
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