## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An efficient synthesis of benzo[b][1,8]naphthyridine-3-carboxylic methyl esters
✍ Scribed by V. Nithyadevi; S. P. Rajendran
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 92 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
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Methyl‐3‐(2‐chloroquinolin‐3‐yl)acrylates 5a‐i on reaction with methyl amine in acetonitrile yielded methyl‐3‐[2‐(methylamino)quinolin‐3‐yl]acrylates 6a‐i. When, these were followed by the reaction with the Vilsmeier reagent, they afforded methyl benzo[b][1,8]naphthyridin‐3‐carboxylate 7a‐i in good yields.
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract A rapid and facile method for the synthesis of novel 5‐amino‐2‐sulfanyl tetrahydrobenzo[__b__][1,8]‐naphthyridine‐3‐carbonitrile derivatives has been developed by the treatment of 2‐amino‐3,5‐dicarbonitrile‐6‐sulfanyl pyridines with cyclohexanone in the presence of anhydrous aluminium c