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An efficient synthesis of benzo[b][1,8]naphthyridine-3-carboxylic methyl esters

✍ Scribed by V. Nithyadevi; S. P. Rajendran


Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
92 KB
Volume
43
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

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Methyl‐3‐(2‐chloroquinolin‐3‐yl)acrylates 5a‐i on reaction with methyl amine in acetonitrile yielded methyl‐3‐[2‐(methylamino)quinolin‐3‐yl]acrylates 6a‐i. When, these were followed by the reaction with the Vilsmeier reagent, they afforded methyl benzo[b][1,8]naphthyridin‐3‐carboxylate 7a‐i in good yields.


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