An efficient synthesis of 6-hydroxyanthranilic acid via ortho-directed metalation
β Scribed by Hillis, Larry R.; Gould, Steven J.
- Book ID
- 119937939
- Publisher
- American Chemical Society
- Year
- 1985
- Tongue
- English
- Weight
- 307 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
## Abstract A new method for the preparation of benzoxazoleβ[phenylβ^13^C~6~] (**1**) starting from anilineβ[^13^C~6~] (**4**) has been developed involving directed __ortho__βmetalation (D__o__M) chemistry. The synthesis comprises four steps and an overall yield of 39% was obtained. Copyright Β© 200
Ortho-substituted aryl ketones are prepared from N-[2-(dimethylamino)ethy]-Nmethylbenzamides via ortho lithiation of intermediate a-amino alkoxides, formed in situ by addition of RLi. also described. An ortho lithiation of N-[2-(dimethylamino)ethyl]-N-methylbenzamide is Tertiary a-amino alkoxides, f