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An Efficient Synthesis of 4,4′-Diaminodiphenic Acid.

✍ Scribed by Arkadiy Rubezhov


Publisher
John Wiley and Sons
Year
2006
Weight
18 KB
Volume
37
Category
Article
ISSN
0931-7597

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An Efficient synthesis of orthogonally p
✍ István Szatmári; Loránd Kiss; Ferenc Fülöp 📂 Article 📅 2006 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 170 KB

A straightforward synthesis of orthogonally N /N -protected trans-and cis-4-aminopipecolic acid is reported, starting from methyl cis-4-hydroxypiperidine-2-carboxylate. The two diastereomers were synthesized with the aid of C-4 inversion (the trans isomer) or double C-4 inversion (the cis isomer).