An Efficient synthesis of orthogonally protected trans- and cis-4-aminopipecolic acid
✍ Scribed by István Szatmári; Loránd Kiss; Ferenc Fülöp
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 170 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
A straightforward synthesis of orthogonally N /N -protected trans-and cis-4-aminopipecolic acid is reported, starting from methyl cis-4-hydroxypiperidine-2-carboxylate. The two diastereomers were synthesized with the aid of C-4 inversion (the trans isomer) or double C-4 inversion (the cis isomer).
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