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An Efficient synthesis of orthogonally protected trans- and cis-4-aminopipecolic acid

✍ Scribed by István Szatmári; Loránd Kiss; Ferenc Fülöp


Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
170 KB
Volume
43
Category
Article
ISSN
0022-152X

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✦ Synopsis


A straightforward synthesis of orthogonally N /N -protected trans-and cis-4-aminopipecolic acid is reported, starting from methyl cis-4-hydroxypiperidine-2-carboxylate. The two diastereomers were synthesized with the aid of C-4 inversion (the trans isomer) or double C-4 inversion (the cis isomer).


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ChemInform Abstract: Practical and Effic
✍ Makoto Tamaki; Guoxia Han; Victor J. Hruby 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

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