✦ LIBER ✦

An efficient synthesis of [2-13C]-monobromoacetic acid

✍ Scribed by I. J. G. Climie; D. A. Evans

Publisher: John Wiley and Sons
Year: 1977
Tongue: French
Weight: 131 KB
Volume: 13
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580130303

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✦ Synopsis

Abstract

[2‐^13^C]‐Monobromoacetic acid was prepared in good yield by the bromination of acetic acid in the presence of phosphorous trichloride by appropriate modification of the method of Marvel.(^1^) A by‐product of this method was found to be bromoacetyl bromide, which could be avoided by hydrolysis to the required product by a modified work‐up procedure. Pure monobromoacetic acid was obtained by sublimation.

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