received in U.K. for publication 8 Iiovember 1971) 11-Desoxyproetaglandlna are of considerable current interest as possible substrates for mlcrobiological hydroxylatlon at C(ll) (pro&mold numbering) and elsewhere, as poaslble antagonlsta of the prostagl&dlns in the E and F series, and as hypotenslve
An efficient route to intermediates for the synthesis of 11-deoxyprostaglandins
β Scribed by Bindra, Jasjit S.; Grodski, Alex
- Book ID
- 126120546
- Publisher
- American Chemical Society
- Year
- 1978
- Tongue
- English
- Weight
- 314 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The iodo lactone I, which has been used as a key intermediate for the synthesis of the six natural primary prostaglandins, is readily available by a synthetic process in which the average yield per step is 95% (l-4). Although the A prostaglandins can be derived from the primary E prostaglandins by d
Reaction of the trimethylsilyl (TMS) enol ethers 6 derived from the conjugate addition of organocopper reagents to 3,4-dimethylcyclopentenone with dimethyl dioximne (DMDO) leads to a-hydroxy ketones 7 with predominantly the syn-methyl orientation. Exposure of these systems to metbanolic lead tetraac
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v