An efficient organocatalyzed multicomponent synthesis of diarylmethanes via Mannich type Friedel–Crafts reaction
✍ Scribed by Atul Kumar; Mukesh Kumar; Maneesh Kumar Gupta
- Book ID
- 104097026
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 449 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
New pyrrolobenzodiazocines 3 have been prepared by an intramolecular Friedel-Crafts process from pyrrolobenzoacrylamides 2. The cyclisation process involving a 1,4-intramolecular addition of a pyrrole onto acrylamide led to the formation of an eight-membered ring.
An efficient Friedel-Crafts reaction of TFA-Asp(Cl)-OMe and stoichiometric amounts of benzene was established by using neat trifluoromethanesulfonic acid (TfOH) as solvent and catalyst under a mild condition. This methodology has been applied to many aromatic compounds and enabled synthesis of sever