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Asymmetric and efficient synthesis of homophenylalanine derivatives via Friedel–Crafts reaction with trifluoromethanesulfonic acid

✍ Scribed by Ryo Murashige; Yuka Hayashi; Makoto Hashimoto

Book ID
104095797
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
237 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient Friedel-Crafts reaction of TFA-Asp(Cl)-OMe and stoichiometric amounts of benzene was established by using neat trifluoromethanesulfonic acid (TfOH) as solvent and catalyst under a mild condition. This methodology has been applied to many aromatic compounds and enabled synthesis of several homophenylalanine derivatives.

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