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An efficient one-pot three-component synthesis of 4-phenyl hexahydro-1H-pyrano[2,3-d]pyrimidin-2(8aH)-one derivatives

✍ Scribed by Srinivasu V. N. Vuppalapati; Rajashekar Bantu Lingaiah; Srinivas Kantevari

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
109 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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An efficient method for the synthesis of a series of 4‐phenylhexahydro‐1H‐pyrano[2,3‐d]pyrimidin‐2(8a__H__)‐one derivatives via the one‐pot three‐component reaction of aromatic aldehydes, urea or thiourea and 3,4‐dihydro‐2__H__‐pyran in DMF/CH~3~CN using p‐TSA catalyst is described. Although three chiral centers are created, only one diastereomer is formed in a highly selective way. This method has several advantages such as higher yield, lower cost, and shorter reaction times. J. Heterocyclic Chem. (2010)

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