An efficient one-pot synthesis of C2-symmetric triazolophanes by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction

✍ Scribed by R. Rajesh; G. Periyasami; R. Raghunathan

• Book ID: 104097457
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 223 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.02.020

✦ Synopsis

A facile and efficient one-pot synthesis of 12-15-membered triazolophanes has been accomplished using CuAAC methodology. The formation of triazolophanes was confirmed by spectral analysis and the products were isolated in good yield. The effect of solvents on this reaction was also studied.