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An efficient method for the synthesis of 1,5-benzodiazepine derivatives under microwave irradiation without solvent

✍ Scribed by Minothora Pozarentzi; Julia Stephanidou-Stephanatou; Constantinos A Tsoleridis

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
177 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

2,3-Dihydro-1H-1,5-benzodiazepines have been synthesized in solvent-free conditions from o-phenylenediamines and ketones in the presence of a catalytic amount of acetic acid, under microwave irradiation. This method is a very easy, rapid and high yielding reaction for the synthesis of 1,5-benzodiazepine derivatives.

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