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An efficient method for synthesis of α-keto acid esters from terminal alkynes

✍ Scribed by Lian-Sheng Li; Yu-Lin Wu

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
133 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

a-Keto acid esters can be easily prepared in high yields in two steps from terminal alkynes via bromination and oxidation. This strategy provides a versatile access to the synthesis of biologically important natural products with an a-keto acid moiety.

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