An efficient method for synthesis of α-k
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Lian-Sheng Li; Yu-Lin Wu
📂
Article
📅
2002
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Elsevier Science
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French
⚖ 133 KB
a-Keto acid esters can be easily prepared in high yields in two steps from terminal alkynes via bromination and oxidation. This strategy provides a versatile access to the synthesis of biologically important natural products with an a-keto acid moiety.