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An efficient enantioselective synthesis of florfenicol via asymmetric aziridination

โœ Scribed by Zhonghua Wang; Feng Li; Lei Zhao; Qiuqin He; Fener Chen; Chen Zheng


Book ID
113928949
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
365 KB
Volume
67
Category
Article
ISSN
0040-4020

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The synthesis of (2R,3S)-and (2S,3R)-hydroxyphenylalanine is reported. The main steps are the 1,4-addition of 0-benzylhydroxylamine to unsaturated imides and the ring expansion of truns-aziridines.