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Asymmetric synthesis of syn hydroxyphenylalanine via aziridine ring expansion to an oxazoline

✍ Scribed by Giuliana Cardillo; Luca Gentilucci; Alessandra Tolomelli

Book ID: 104262512
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 222 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01734-7

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✦ Synopsis

The synthesis of (2R,3S)-and (2S,3R)-hydroxyphenylalanine is reported. The main steps are the 1,4-addition of 0-benzylhydroxylamine to unsaturated imides and the ring expansion of truns-aziridines.

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