An efficient, enantioselective synthesis of branched polyhydroxylated pyrrolidines
โ Scribed by Mark F Mechelke; A.I Meyers
- Book ID
- 104211003
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 87 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The enantioselective synthesis of branched polyhydroxylated pyrrolidines from a novel a-methylene bicyclic lactam (4b) is described.
๐ SIMILAR VOLUMES
The Efficient, Enantioselective Synthesis of Aza Sugars from Amino Acids. Part 1. The Polyhydroxylated Pyrrolidines. -All eight stereoisomeric 2-hydroxymethyl-3,4-dihydroxypyrrolidines, e. g. (IX) and (X), are prepared from L-serine methylester (I) or D-serine methylester, respectively. Key step in
Several polyhydroxylated pyrrolidines with an aliphatic long chain on the ring nitrogen were prepared starting from D-mannitol. An amphiphilic bis-azasugar scaffold has been also prepared. These products behave as cationic surfactants and show a promising anti HIV-1 activity.