A simple method to introduce an heteroatom substituent at C-5 of isothiazole dioxides is reported. Through Michael addition reaction 5-substituted isothiazole and 4,5-dihydroisothiazole 1,1-dioxides were obtained allowing the preparation of a series of derivatives of special interest for biological
An Efficient Diastereoselective Route to Differentially Protected anti-4-Amino-1-alken-3-ols.
β Scribed by Marco Lombardo; Elisa Mosconi; Filippo Pasi; Marino Petrini; Claudio Trombini
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 37 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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Isothiazoles. Part 9. An Efficient Synthetic Route to 5-Substituted-3-amino-4-arylisothiazole 1,1-Dioxides and Their 4,5-Dihydro Derivatives. -The thiazole dioxide (I) does not react with alcohols, while the derivative (VIII) does not undergo addition with aliphatic and aromatic amines but with the
## Abstract By a oneβpot tandem __Ugi__ multicomponent reaction (MCR)/click reaction sequence not requiring protecting groups, 1__H__β1,2,3βtriazoleβmodified __Ugi__βreaction products **6a**β**6n** (__Schemeβ 1__ and __Tableβ 2__), **7a**β**7b** (__Tableβ 4__), and **8** (__Schemeβ 2__) were synthesize