An Efficient Copper-Catalyzed Cross-Coupling Reaction of Thiols with Aryl Iodides
β Scribed by Hsin-Lun Kao; Chin-Keng Chen; Yu-Jen Wang; Chin-Fa Lee
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 347 KB
- Volume
- 2011
- Category
- Article
- ISSN
- 1434-193X
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π SIMILAR VOLUMES
## Abstract A copperβcatalyzed crossβcoupling reaction of alkynes with aryl iodides is described. The system tolerates a broad range of functional groups and enables the use of sterically demanding substrates with only 1.0β2.5 molβ% of Cu~2~O and 1.0β2.5 molβ% of xantphos as the catalyst.
## Abstract A general, economical and efficient protocol for the direct copperβcatalyzed coupling of thiourea with aryl iodides is developed and it will be potentially applied in largeβscale industry as a preferred process.