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An efficient chiral synthesis of (+)-sesbanine

โœ Scribed by Kiyoshi Tomioka; Kenji Koga


Book ID
104225381
Publisher
Elsevier Science
Year
1980
Tongue
French
Weight
209 KB
Volume
21
Category
Article
ISSN
0040-4039

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Racemic sesbanine was synthesized by using regioselective ortho lithiation of N,N-dialkylnicotinamides and subsequent condensation with 3cyclopentenone as key reactions. Diverse synthetic utility of tertiary amide-directed metalation of aromatic substrates has been demonstrated by Snieckus and co-wo