An efficient chemoenzymic access to optically active myo-inositol polyphosphates
β Scribed by Da-Ming Gou; Yeuk-Chuen Liu; Ching-Shih Chen
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 985 KB
- Volume
- 234
- Category
- Article
- ISSN
- 0008-6215
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β¦ Synopsis
The 1,4,5-tris-, 1,3,4-tris-, and 1,3,4,5-tetrakis-phosphates of lo-myo-inositol have been prepared in their enantiomerically pure forms from the two enantiomers of 1,2:5,6-di-O-cyclohexylidene-myo-inositol. A facile enzymic preparation is also described of these chiral intermediates through enantiospecific deacylation of the corresponding racemic esters.
π SIMILAR VOLUMES
An effective synthesis of IJ-w-inositol 1,4,5\_triphosphate was developed using a chiral inositide precursor which can be prepared via a facile enzymatic or chemical method. Recently, much attention has been focused on the metabolic cascade of membrane phosphoinositides, which regulates intracellula
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