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An efficient asymmetric synthesis of (2S,3S)- and (2R,3R)-β-hydroxyornithine
✍ Scribed by Duane E DeMong; Robert M Williams
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 80 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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Abstmctz A convenient new asymmetric synthesis of both enaatiomcrs of eryrhro-3-hydroxylcuciae is desctibed. The key steps involve Sharpless asymmetric dihydroxylation (AD) of a&unsaturated ester 3, cyclic sulphate formation from the resulting diol, SNZ reaction with sodium azide, deesterification w
An efficient synthesis of the natural occuring amino acid (2S.3R)-3-hydroxylysine is reported. The five step sequence features a highly enantioselective dynamic kinetic resolution of racemic o~acetamido [J-keto phtidimidohexanoate using ruthenium(ll) catalyzed hydrogenation reaction.