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An efficient asymmetric synthesis of 1.alpha.,25-(OH)2 vitamin D3 A-ring synthon

✍ Scribed by Nagasawa, Kazuo; Ishihara, Hideki; Zako, Yoshiro; Shimizu, Isao


Book ID
126995352
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
1002 KB
Volume
58
Category
Article
ISSN
0022-3263

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An efficient enantioselective synthesis
✍ Masakazu Koiwa; Georges P.J Hareau; Fumie Sato πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 99 KB

The asymmetric synthesis of the A-ring of 1Ξ±,25-dihydroxyvitamin D 3 , (Z)-2, from 5-tert-butyldimethylsiloxy-2-cyclohexenone [(S)-1], is described where an intramolecular lactonization using cat. scandium triflate is the key reaction.