An Efficient Asymmetric Domino Reaction of Amino Aldehyde to β , γ -Unsaturated α -Keto Esters Using trans -Perhydroindolic Acid as a Chiral Organocatalyst
✍ Scribed by Shen, Jiefeng; An, Qianjin; Liu, Delong; Liu, Yangang; Zhang, Wanbin
- Book ID
- 118757201
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 406 KB
- Category
- Article
- ISSN
- 0256-7660
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## Abstract A very simple and efficient synthesis of 3‐amino‐1,5‐dihydro‐2__H__‐pyrrol‐2‐ones is reported. These cyclic dehydro‐amino acid derivatives with a stereogenic center at the 5‐position were obtained by the addition of two equivalents of amine to β,γ‐unsaturated keto esters. These cyclic e