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An Efficient and Large-Scale Enantioselective Synthesis of PNP405: A Purine Nucleoside Phosphorylase Inhibitor

✍ Scribed by Prashad, Mahavir; Har, Denis; Chen, Lijian; Kim, Hong-Yong; Repič, Oljan; Blacklock, Thomas J.


Book ID
115450580
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
140 KB
Volume
67
Category
Article
ISSN
0022-3263

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Synthesis of deuterated-BCX-1777, a pote
✍ Hollis S. Kezar III; Tracy L. Hutchison; Peter C. Tyler; Philip E. Morris Jr. 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 112 KB

## Abstract BCX‐1777, a novel inhibitor of the enzyme purine nucleoside phosphorylase, mimics the charged ribosyl oxocarbenium ion formed during the transition state of the enzyme‐catalyzed CN bond cleavage of nucleosides. BCX‐1777 is a slow‐onset, tight‐binding inhibitor with a __K__~__i__~^\*^ o