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An efficient and greener protocol towards synthesis of unsymmetrical N,N′-biphenyl urea

✍ Scribed by Mane, Madhav; Balaskar, Ravi; Gavade, Sandip; Pabrekar, Pramod; Mane, Dhananjay


Book ID
123195496
Publisher
Elsevier
Year
2013
Tongue
English
Weight
545 KB
Volume
6
Category
Article
ISSN
1878-5352

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A new method for producing unsymmetrical, tetrasubstituted ureas from N, N'carbonyldiimidazole (CDI) is presented. Carbamoyl imidazolium salts are prepared from the reaction of CDI with a secondary amine, followed by alkylation with MeI. Secondary amines add with ease to imidazolium salts at room te