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Synthesis of unsymmetrical biaryl ureas from N-carbamoylimidazoles: kinetics and application

โœ Scribed by Tristan Rawling; Andrew M. McDonagh; Bruce Tattam; Michael Murray


Book ID
116909459
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
574 KB
Volume
68
Category
Article
ISSN
0040-4020

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The synthesis of Boc-or Fmoc-monoprotected propylenediamine derivatives is reported starting from N-protected a-amino acids. The introduction of these building blocks on solid support via the formation of a urea moiety leads to a new pseudopeptide family (Ca-CHe-CH~-Na(R)-CO-NH-Ca). Two carbonylati