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An efficient and facile synthesis of substituted cinnoline and benzo[h]cinnoline derivatives

✍ Scribed by Mohsen Abdel-Motaal Gomaa

Book ID: 104253475
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 125 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00686-5

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✦ Synopsis

New substituted 3-amino-5,7,8-trihalo-6-hydroxycinnoline-4-carbonitriles 7 and 8 and the 3-amino-5-chloro-6-hydroxybenzo[h]cinnoline-4-carbonitrile 9 were synthesized in two-steps starting from tetrahalo-1,4-benzoquinones or dichloro-1,4-naphthoquinones, malononitrile and hydrazine.

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