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A practical synthesis of substituted benzo[c]cinnoline- N,N′-dioxides and N-oxides.

✍ Scribed by Cristina Paradisi; Guadalupe González-Trueba; Gianfranco Scorrano


Publisher
Elsevier Science
Year
1993
Tongue
French
Weight
136 KB
Volume
34
Category
Article
ISSN
0040-4039

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A series of 3-halomethyl-5,6-dihydro-1,2-oxazine N-oxides (halogen = Cl, Br, I) is prepared from 4-phenyl-3,6,6-trimethyl-5,6-dihydro-4H-oxazine N-oxide by means of a silylation/halogenation sequence. The obtained halogenated N-oxides undergo reactions typical of cyclic six-membered nitronates inclu