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An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media

โœ Scribed by Gawande, Manoj B.; Branco, Paula S.


Book ID
111961437
Publisher
Royal Society of Chemistry
Year
2011
Tongue
English
Weight
241 KB
Volume
13
Category
Article
ISSN
1463-9262

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An efficient "one-pot" conversion of Fmoc-protected amino acids to the ureas in the solid phase is described. This methodology uses MeSiCI3 in the presence of Et3N to cleave Fmoc-protected amines directly to their isocyanates. This transformation has been demonstrated on some Fmocprotected amino aci